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Review Article | OPEN ACCESS

Transdermal Spray in Hormone Delivery

Evren Algın-Yapar1 , Özge İnal2

1The Ministry of Health of Turkey, Turkish Medicines and Medical Devices Agency, Söğütözü Mahallesi, 2176. Sokak No. 5, 06520 Çankaya-Ankara; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, 06100 Tandoğan- Ankara, Turkey.

For correspondence:-  Evren Algın-Yapar   Email: evren.yapar@yahoo.com   Tel:+9005323825686

Received: 23 July 2012        Accepted: 15 February 2014        Published: 24 March 2014

Citation: Algın-Yapar E, İnal &. Transdermal Spray in Hormone Delivery. Trop J Pharm Res 2014; 13(3):469-474 doi: 10.4314/tjpr.v13i3.23

© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

This review examines advances in hormone delivery, particularly using transdermal spray. Transdermal gels, emulsions, patches, subcutaneous implants and sprays have been developed for transdermal hormone therapy in recent years. Transdermal sprays, in their general form of metered-dose transdermal spray, possess major advantages such as enhanced passive transdermal drug delivery with little or no skin irritations, improved cosmetic acceptability, dose flexibility, uniform distribution on the application site and ease of manufacture, and have thus assumed significant importance in hormone delivery. Estradiol, nestrone, testosterone and hydrocortisone aceponate are some of the drugs prepared as metered-dose transdermal spray. Results from recent surveys indicate that there is a market for the delivery system and ongoing development of transdermal sprays for hormone delivery.

Keywords: Transdermal, Delivery systems, Metered dose, Spray, Hormone

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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